Clarks River National Wildlife Refuge is mainly bottomland hardwood forest habitat along the East Fork of the Clarks River in western Kentucky. This makes it a popular location for upland game, turkey and deer hunting. The most-hunted species at the refuge is deer, with significant use by residents and non-residents. Annual hunt/fish permits are available at Rec Access. The permit type and associated fee can be found below:
| Youth Under 16 | Free, no permit needed |
| Age 16 - 64 | $14 |
| Age 65 and Over | $4 |
| Active Military /Veterans | $4 |
| All Waterfowl Lottery Applications | $6 |
Hunters may pursue waterfowl on refuge lands during state seasons. Annual quota waterfowl hunts are held for hunt dates during the state season except during modern gun and muzzleloader deer seasons. Applications for the quota hunt will be accepted September 1st through October 15th each year. Quota hunt applications can be accessed at Rec Access for a fee of $6.
Hunters with disabilities may apply at the refuge office for a special-use permit for all-terrain vehicle (ATV) use. Hunters are encouraged to start this process well before their designated season opens.
