The refuge participates in the annual Wings Over Water festival, held each October. This wildlife festival raises funds for the refuges and includes over 90 trips & programs involving birding, paddling, photography, art, and natural history. Activities take place in six northeastern North Carolina counties and six national wildlife refuges, including Mattamuskeet. The event website can be found here: https://www.wingsoverwater.org/
Each December the refuge hosts an annual Open House where visitors may enjoy tours of a part of the refuge which is normally closed to public access in the winter.