Oxytetracycline is a broad-spectrum antibiotic with bacteriostatic properties that is active against a wide variety of gram-positive and gram-negative bacteria (Hochstein et al. 1953). As a chemotherapeutant, it can be administered via enteral or parenteral routes with good tissue distribution (Stoffregen et al. 1996). Since its isolation and development in 1950, OTC has become one of the most commonly used antibiotics in aquaculture (Xu and Rogers 1994; Rigos et al. 2004).
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