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In addition to decisions on individual threatened and endangered species, some of the key conservation issues involving the U.S. Fish and Wildlife Service include:

- Arctic National Wildlife Refuge
- Alaska Subsistence
- Amphibian Declines and Deformities
- Bird Conservation
- Coral Trade
- Cyanide Mine Wastes

- Fisheries and Federal Aid
- Invasive Species
- Migratory Birds
- Pesticides and Wildlife
- Tibetan Antelope and Shahtoosh
- Wildfire, the Endangered Species Act, and Human Safety

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