Fish and Aquatic Conservation


OvaRH® Salmon Gonadotropin – Releasing Hormone analogue (sGnRHa)
INAD #12-186

Illustration of Cutthroat trout. Credit: Timothy Knepp/USFWS

Summary

OvaRH® is a synthetic peptide analogue of salmon gonadotropin-releasing hormone (sGnRHa). It is presented as a soluble powder for dissolution in saline as an injection either as an intraperitoneal (IP) or intramuscular (IM) injection. OvaRH® is only available for purchase through Syndel USA. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that needs hormone treatment to complete final gamete maturation to ensure spawning. The primary goal of field studies conducted under INAD #12-186 is to generate data to help determine appropriate OvaRH® treatment regimens for inducing gamete maturation in a variety of freshwater and marine finfish. Fish may be treated up to 50 microgram (µg) OvaRH® per kilogram body weight with single or multiple injections. Multiple injections will generally consist of a single “priming dose,” followed by a single “resolving dose.” A 14 day Investigational withdrawal period has been set for treated fish. To participate in the INAD Program for OvaRH® visit the data collecting site.

Please read the Study Protocol prior to any treatments. It contains the protocol, MSDS, and a copy of the forms to be used as a guide for collecting data that will be entered into the online INAD database. The FDA authorization letter(s) for this INAD is currently only available by emailing Bonnie Johnson.


INAD objective/purpose: Collect supportive and pivotal data needed to establish the effectiveness of sGnRHa/OvaRH® to induce gamete maturation in a variety of fish species.

Drug Name
OvaRH®; Salmon Gonadotropin - Releasing Hormone analogue (sGnRHa)

Drug Source
Syndel USA
1441 W Smith Rd,
Ferndale, WA 98248 USA

Jason Montgomery
Phone: 800-283-5292
Fax: 360-384-0270
email: jasonm@syndel.com
Website: www.syndel.com

Target pathogen(s): Not Applicable

Method of administration: IM or IP injection

Treatment dosage:

  • Total dosage will not exceed 50 microgram (μg) OvaRH per kilogram body weight

Treatment regimen:

  • Single or multiple treatment. Multiple treatment will generally consist of a single "priming dose," followed by a single "resolving dose." Administered IP or IM.

Investigational Withdrawal period:

  • 14 days for all fish.

Required test parameters:

  • Investigator must collect data reporting percent ovulation and/or percent spermiation in treated fish. Investigator should also report general fish behavior and any adverse effects relating to treatment.

Limitations or restrictions on use of drug:

  • Investigator must follow all instructions in the Study Protocol for INAD 12-186 regarding drug acquisition and handling, fish treatment and disposition, and data reporting requirements.
  • Drug discharge must be in compliance with local NPDES permitting requirements.

Required INAD fee: $700/facility/year

AADAP Contact Information:
Ms. Bonnie Johnson, FWS-AADAP
Phone: 406-994-9905
Fax: 406-582-0242
email: bonnie_johnson@fws.gov