Fish and Aquatic Conservation

Common Carp Pituitary (CCP) INAD #8391

Muskellunge (Esox masquinongy), in aquarium at Gavins Point National Fish Hatchery, South Dakota. Credit: Brett Billings/USFWS


Common carp pituitary (CCP) is a powder (for suspension) that is applied as either an intraperitoneal (IP) or intramuscular (IM) injection. CCP is only available for purchase through Argent Aquaculture. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that need hormone treatment to complete final gamete maturation to ensure spawning. The primary goal of field studies conducted under INAD #8391 is to generate data to help determine appropriate CCP treatment regimens for inducing gamete maturation in a variety of cultured and wildstock finfish species. Fish may be treated at a standard dosage rate of 4 to 10 milligrams (mg) CCP per kilogram (kg) body weight with single or multiple IP or IM injections. Although certain situations may require a higher dosage rate, dosage will never exceed 25 (mg) CCP per kilogram (kg) body weight. Multiple injections will generally consist of a single “priming dose,” followed by a single “resolving dose.” Fish treated with CCP can be released back into their natural environment or slaughtered for food immediately after spawning (i.e., no Investigational withdrawal period). To participate in the INAD Program for CCP visit the data collecting site.

Please read the Study Protocol prior to any treatments. It contains the protocol, MSDS, and a copy of the forms to be used as a guide for collecting data that will be entered into the online INAD database. The FDA authorization letter(s) for this INAD is currently only available by emailing Bonnie Johnson.

INAD objective/purpose: Collect supportive and pivotal data needed to establish the effectiveness of Common Carp Pituitary (CCP) to induce gamete maturation in a variety of fish species.

Drug Name
Common Carp Pituitary

Drug Source
Argent Aquaculture
8547 152nd Ave NE
Redmond, WA 98052

Phone: 425-605-0933

Target pathogen(s): Not Applicable

Method of administration: IM or IP injection

Treatment dosage:

  • Standard dosages rates are 4-10 milligrams (mg) CCP per kilogram (kg) body weight.
  • Not to exceed 25 milligrams (mg) CCP per kilogram (kg) bod

Treatment regimen:

  • Single or multiple treatment. Multiple treatment will generally consist of a single "priming dose," followed by a single "resolving dose."

Investigational Withdrawal period:

  • A zero day withdrawal period is in place for treated fish.

Required test parameters:

  • Investigator must collect data reporting percent ovulation and/or percent spermiation in treated fish. Investigator should also report general fish behavior and any adverse effects relating to treatment.

Limitations or restrictions on use of drug:

  • Investigator must follow all instructions in the Study Protocol for INAD 8391 regarding drug acquisition and handling, fish treatment and disposition, and data reporting requirements.
  • Drug discharge must be in compliance with local NPDES permitting requirements.

Required INAD fee: $700/facility/year

AADAP Contact Information:
Ms. Bonnie Johnson, FWS-AADAP
Phone: 406-994-9905
Fax: 406-582-0242