Fish and Aquatic Conservation

Channel Catfish Pituitary (CP) INAD #11-468

Channel catfish (Ictalurus punctatus) in aquarium at Gavins Point National Fish Hatchery, South Dakota
Credit: Brett Billings/USFWS


Channel catfish pituitary (CP) is a powder (for suspension) that is applied as either an intraperitoneal (IP) or intramuscular (IM) injection. CP is only available for purchase through Hybrid Catfish Company. The use of hormones to induce spawning in fish is critical to the success of many aquatic programs that needs hormone treatment to complete final gamete maturation to ensure spawning. The primary goal of field studies conducted under INAD #11-468 is to generate data to help determine appropriate CP treatment regimens for inducing gamete maturation in various catfish species. Fish may be treated at a standard dosage rate will be 10 milligrams (mg) CP per kilogram (kg) body weight with single or multiple IP or IM injections. Although certain situations may require a higher dosage rate, dosage will never exceed 25 (mg) CP per kilogram (kg) body weight. Multiple injections will generally consist of a single “priming dose,” followed by a single “resolving dose.” Adherence to a 3-day Investigational withdrawal period is required for all fish treated with CP under this INAD. To participate in the INAD Program for CP visit the data collecting site.

Please read the Study Protocol prior to any treatments. It contains the protocol, MSDS, and a copy of the forms to be used as a guide for collecting data that will be entered into the online INAD database. The FDA authorization letter(s) for this INAD is currently only available by emailing Bonnie Johnson.

INAD objective/purpose: Collect scientific data necessary to establish the efficacy of Channel Catfish Pituitary (CP) on gamete maturation in a variety of catfish species.

Drug Name
Channel Catfish Pituitary

Drug Source
Hybrid Catfish Company
1233 Montgomery Dr
Inverness, MS 38753

Roger Yant
Phone: 662-207-0461

Target pathogen(s): Not Applicable

Method of administration: IM or IP injection

Treatment dosage:

  • 10 milligram (mg) CP per kilogram (kg) body weight
  • Although certain situations may require a higher dosage rate, dosage will never exceed 25 mg CP/kg body weight

Treatment regimen:

  • Single or multiple treatments. Multiple treatments will generally consist of a single “priming dose”, followed by a single “resolving dose”.

Investigational Withdrawal period:

  • 3 days

Required test parameters:

  • Investigator must collect data reporting percent ovulation and/or percent spermiation in treated fish. Investigator should also report general fish behavior and any possible adverse effects relating to treatment.

Limitations or restrictions on use of drug:

  • Investigator must follow all instructions in the Study Protocol for INAD 11-468 regarding drug acquisition and handling, fish treatment and disposition, and data reporting requirements.
  • Drug discharge must be in compliance with local NPDES permitting requirements.

Required INAD fee: $700/facility/year

AADAP Contact Information:
Ms. Bonnie Johnson, FWS-AADAP
Phone: 406-994-9905
Fax: 406-582-0242