Grulla National Wildlife Refuge is located in Roosevelt County, New Mexico, near the small town of Arch, approximately 25 miles northwest of Muleshoe National Wildlife Refuge. Grulla NWR, which is managed by the staff at Muleshoe NWR, is 3,236 acres, more than 2,000 of which is the saline lake bed of Salt Lake. The rest of the refuge is grassland.

When the lake holds sufficient water, Grulla NWR is a beneficial wintering area for lesser sandhill cranes. Ring-necked pheasant, scaled quail, and lesser prairie chicken are also often seen on or near the refuge.