The Oklahoma Fish and Wildlife Conservation Office is located in south-central region of the state near Tishomingo, Oklahoma.
The office is co-located at the Tishomingo National Fish Hatchery beside Pennington Creek, the water supply for the hatchery. The facilities are located 10 miles northwest of Tishomingo, Oklahoma, on State highway 7 near the small community of Reagan. Office space, garage facilities, and an equipment storage area are provided by the hatchery.
The Oklahoma FWCO collaborates with other agencies and organizations to monitor the health of Oklahoma's aquatic ecosystems, protect and restore populations of threatened and endangered species, and eradicate or control invasive species across the state.