Directions to Santee NWR
From I-95 (North or South):
Take Hwy. 15/301 exit on North side of Lake Marion (exit 102).
From I-26 East (Charleston): approximately 1 hour
Take I-26 to I-95. Take I-95 North until you reach exit 102 (Hwy 15/301).
From I-26 West (Columbia): approximately 1 hour
Take I-26 to 301 East (towards Santee). Go approximately 16 miles to Santee, where 301 will turn onto I-95 North. Take I-95 North for approximately 4 miles to exit 102.
From Hwy. 15/301:
Follow signs to visitor Center.
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Hours of Operation:
8:00 am - 4:00 pm Tuesday - Friday
Refuge trails and grounds are open daily sunrise to sunset, EXCEPT on Cuddo:
October 1 - February 28 - 7:00 am - 5:00 pm
March 1 - September 30 - 6:00 am - 8:00 pm