Hours of Operation:
8:00 am - 4:00 pm Tuesday - Friday
Refuge trails and grounds are open daily sunrise to sunset, EXCEPT on the Cuddo and Bluff Units, which are open as noted below:
The Cuddo Unit is open Tuesday-Sunday
October 1 - February 28 - 7:00 am - 5:00 pm
March 1 - September 30 - 6:00 am - 8:00 pm
Due to projected construction activity the Cuddo Unit wildlife drive may be periodically closed due to visitor safety concerns. Please check with the refuge office for updates of projected closures before you visit.
Directions to Santee NWR:
From I-95 (North or South):
Take Hwy. 15/301 exit on North side of Lake Marion (exit 102).
From I-26 East (Charleston): approximately 1 hour: Take I-26 to I-95. Take I-95 North until you reach exit 102 (Hwy 15/301).
From I-26 West (Columbia): approximately 1 hour: Take I-26 to 301 East (towards Santee). Go approximately 16 miles to Santee, where 301 will turn onto I-95 North. Take I-95 North for approximately 4 miles to exit 102.
From Hwy. 15/301:
Follow signs to visitor Center.
Click here for larger map.