Raptors are common year-round. During the spring and summer months, common species include turkey vulture, Mississippi kite, American kestral, red-tailed hawk, Swainson's hawk, and ferruginous hawk. Species common in the fall and winter months are bald and golden eagles, prairie falcon, rough-legged hawk, and Cooper's hawk. Resident game birds include the Rio Grande turkey, ring-necked pheasant, bobwhite quail, and scaled quail.

A variety of mammals are also found on the refuge including white-tailed and mule deer, bobcat, coyote, beaver, porcupine, black-tailed jackrabbit, badger, raccoon, and skunk. Reptiles include the prairie rattlesnake and the Texas horned lizard.