Seatuck National Wildlife Refuge is actively managed for migratory birds, particularly waterbirds and raptors, and to maintain and enhance habitat diversity.
Both upland and wetland habitats at the Seatuck Refuge are actively managed. Wetland management activities conducted at the refuge include restoring tidal flow, blocking manmade drainage ditches, open marsh water management, and wood duck nest box maintenance. Upland management activities include erecting osprey nesting platforms, brush hogging grasslands and upland shrub habitats, prescribed burning, restoring derelict lands to native habitat, white-tailed deer management, songbird nest box program, and an owl monitoring program which is conducted by the South Shore Audubon Society.
Wildlife monitoring conducted at the refuge includes waterbird surveys, migratory songbird and raptor surveys, white-tailed deer counts, and mosquito sampling.