
Prior to European colonization, the land making up the refuge and surrounding Colfax County were a source of food and an area of trade for several Native American nations, including the Comanche, Apache, Kiowa, and Ute.
Evidence of European settlement still exists. Remnants of the Santa Fe Trail are within two miles of the refuge boundary. Beginning in 1821, the 900 mile trail served as the main trading route for western settlers between Missouri and Santa Fe for more than 60 years.