From Norfolk and Currituck Area:

Take US 168 south. US 168 becomes US 158 about 18 miles south of the NC/VA line. Continue on US 158 for about 23 miles. At this point you will cross the Wright Memorial Bridge across the Currituck Sound. After the bridge continue on US 158 through Kitty Hawk, Kill Devil Hills, and Nags Head. At the south end of Nags Head, you will see signs for Hatteras Island, Cape Hatteras National Seashore, and NC 12 south. You will make a left at a traffic light onto NC 12 south. Almost immediately you will pass through another traffic light and will now be on NC 12 south. Follow NC 12 south for approximately 8 miles. Cross the Herbert C. Bonner Bridge across Oregon Inlet. On the south side of the bridge you will see the refuge entrance sign on your right. Approximately 4 miles south on the right is the Visitor’s Center and an informational kiosk providing information on trails and visitor opportunities.

From Raleigh Area:

Take US 64 east from Raleigh. Travel east on US 64 for approximately 3 hours (at posted highway speeds). Approximately 12 miles west of the town of Columbia, US 64 will cross the Alligator River. On the east side of the bridge you will see a sign for Alligator River National Wildlife Refuge. Continue east through this refuge on US 64. US 64 will join with US 264 to become US 64/264. Continue east through the town of Manns Harbor on US 64/264 and cross the bridge to Roanoke Island. Here you will continue east on US 64/264 across 1 tall bridge and 1 small bridge. After the small bridge you will see signs for Hatteras Island, Cape Hatteras National Seashore, and NC 12 south. Take a right onto NC 12 south. Follow NC 12 south for approximately 8 miles. Cross the Herbert C. Bonner Bridge across Oregon Inlet. On the south side of the bridge you will see the refuge entrance sign on your right. Approximately 4 miles south on the right is the Visitor Center and an informational kiosk providing information on trails and visitor opportunities.