Drug Summary & History
CCP INAD 8391

The use of hormones to induce gamete maturation (ovulation and spermiation) and spawning in fishes is crucial to the success of many aquaculture and wildstock fisheries programs. World-wide, common carp pituitary (CCP) has long been used (and remains the most frequently used material) to induce gamete maturation in fishes. Thus, CCP has been identified as a candidate for approval for the above-described use by the U.S. Food and Drug Administration.

The primary goal of field studies conducted under INAD #8391 is to generate data to help determine appropriate CCP treatment regimens for inducing gamete maturation in a variety of cultured and wildstock fish species. Under this INAD, Stoller Fisheries (Spirit Lake, IA) and Argent Chemical Company (Redmond, WA) are the authorized CCP suppliers to all Investigators. One treatment option (injectable) is recommended (see below). Disposition of investigational animals (including withdrawal time) will vary with treatment specifics.

Treatment Option (injectable): Administer as an intraperitoneal (IP) or intramuscular (IM) injectable. Standard dose rates are 4 - 10 mg CCP/kg body weight (not to exceed 25 mg CCP/kg body weight). Single or multiple (usually two) treatments may be administered. If two treatments are administered, the first will be the “priming” dose, and the second will be the “resolving” dose.