| The
following links are specific to:
Calcein
Drug
summary & history
List of FDA-Approved drugs
Drug forms to be completed
Generic examples of completed forms
INAD
study protocol
Material
Safety Data Sheet
(MSDS)
Study
Summaries
Print
this drug fact sheet
Print
all drug fact sheets
INAD
signup form (Federal facilities)
INAD signup form (other facilities)
Information on EPA's National Pollutant Discharge Elimination System (NPDES) Permits
Relevant literature, technical publications, etc. |
| Objective/purpose: |
Collect
supportive and pivotal data needed to establish the effectiveness
of calcein to mark fin rays, scales, otoliths, and other calcified
fish or selected mussel tissues, via immersion baths. |
| Drug name: |
SE-MARK® (Calcein)
|
| Source of drug: |
Western
Chemical, Inc. |
Address:
|
1269 Lattimore Road
Ferndale, WA 98248 USA |
Contact:
|
Attention: Ron Malnor
Toll Free: 800-283-5292
email: ronm@wchemical.com
|
| Target
pathogen(s): |
Not Applicable |
| Method
of administration: |
Immersion:
standing-bath treatment only |
| Treatment
dosage: |
Option
A: 125 - 250 milligrams calcein per liter
Option B: 2.5 - 5.0 grams calcein per liter (finfish only) |
| Treatment
regimen: |
Option
A: Treatment duration is 1 - 6 hours
Option B: Treatment duration is 1 - 7 minutes (Note: Treatment
may include a pre-treatment with a 1 - 5% salt solution for
~3.5 minutes.)
Calcein
may be applied as a single treatment, or repeated treatments. |
| Withdrawal
period: |
None for fish; they
may be released immediately following treatment for those treated at less than 2 grams and for Federally Threatened and Endangered species.
None for mussels; due to their treatment at an early life stage and the limited human consumption |
| Required
test parameters: |
Investigator
must collect mark retention and mortality data. Investigator
should also report general fish behavior and any adverse effects
relating to treatment. |
| Limitations
or restrictions on use: |
Treatment
is restricted to finfish having a body weight of 2 grams or less.
Treatment
of mussels is restricted to the following species: Higgins eye, hickory nut, black sandshell, pocketbook, fat mucket, sheepnose and maple leaf.
Repeated treatments may be conducted to establish mutltiple marks. However, an interval of at least 2 days should be observed between treatment events.
No discharge
of calcein marking solution is allowed. Although used calcein marking
solution may be stored on station in a secure, leak-proof
container, it must ultimately be disposed of according to
procedures detailed in a general Waste-stream profile (see
INAD Study Protocol for specific instructions).
Investigator must follow all instructions in the Study Protocol
for INAD 10-987 regarding drug acquisition and handling, fish
treatment and disposition, and data reporting requirements.
|
| Required
INAD fee: |
$400.00
per facility per year |
| AADAP
contact for other information: |
Ms.
Bonnie Johnson, FWS - AADAP
Phone: 406-994-9905
Fax: 406-582-0242
bonnie_johnson@fws.gov |
| Disclaimer: |
Product and company names mentioned in this website, or mentioned in materials accessed via this website, are for informational purposes only. The mention of such does not imply endorsement by the Aquatic Animal Drug Approval Partnership, the U.S. Fish & Wildlife Service or any other organization of the U.S. Government. |
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