FDA's Phish-Pharm Database of searchable pharmacokinetics data for fish ...
Phish-Pharm was first released in 2005 (and recently updated in late 2006), accompanying an article in the American Association of Pharmaceutical Scientists (AAPS) Journal:
Fish Drug Analysis-Phish-Pharm: A Searchable Database of Pharmacokinetics Data in Fish, by R. Reimschuessel, L. Stewart, E. Squibb, K. Hirokawa, T. Brady, D. Brooks, B. Shaikh, C. Hodsdon. 2005. AAPS Journal. Vol 07(02): E288-E327, article 30, http://www.aapsj.org/view.asp?art=aapsj070230.
The database can be freely downloaded in the form of a Microsoft Office Access file which can be easily searched, a stand alone Access Application or an Excel spreadsheet. This information in the database was gathered from over 400 articles, including data from 124 species (95 genera). Data fields include genus, species, water temperatures, the average animal weight, sample types analyzed, drug (or chemical) name, dosage, route of administration, metabolites identified, method of analysis, protein binding, clearance, volume of distribution in a central compartment (Vc) or volume of distribution at steady-state (Vd), and drug half-lives (t½). Additional fields list the citation, authors, title, and Internet links. The document will be periodically updated, and users are invited to submit additional data.
Additional updates will be announced as they are available. This database is a valuable resource to investigators of drug metabolism in aquatic species as well as government and private organizations involved in the drug approval process for aquatic species.
The following are links to the several versions of the Database (all, except HTML Version are large files):
Microsoft Access version: must have MS Access already installed on your computer (6.6 MB file)
Application Version: Microsoft Access not required; download & install ONLY if you DO NOT HAVE MS Access installed on your computer (35.3 MB zipped file)
HTML Version: non-searchable version
Microsoft Excel Version (3.0 MB file)
If any of the above links fails to load, or otherwise malfunctions, go to the following FDA site: