Located in Mississippi County, AR, 18 miles west of the Mississippi River.

The refuge headquarters is located 2.5 miles east of Manila on Highway 18 and 15 miles west of Blytheville. The refuge is open year-round for daylight use only. Occasionally portions of the refuge may be closed due to flooding. Persons planning a visit to Big Lake National Wildlife Refuge should contact the headquarters at 870-564-2429 for the latest conditions.